Melatonin, a hormone produced by the pineal gland, governs, regulates, and supports the biological rhythm and circadian rhythm. It is commonly used in nutraceuticals to address sleep issues, effectively combating insomnia or jet lag. Additionally, melatonin affects several organs, with potentially beneficial or harmful impacts.
This article explores the overall effects of melatonin on two vital human organs: the liver and the heart. You will also find information on natural alternatives for supporting the heart, liver, and sleep.
What are the potential side effects of melatonin on the liver and heart?
Although surprising, several correlations exist between melatonin and the liver, as highlighted in this article.
Primarily synthesized by a gland in the brain, melatonin is also produced in smaller amounts by other structures in the body (such as the retina, skin, and bone marrow). Among these, the intestine—and by extension, the liver—plays a role. Furthermore, a significant proportion of melatonin (90% of circulating melatonin) is metabolized in the liver.
However, as we age, melatonin production naturally declines, leading to side effects such as fatigue, sleep disturbances, high cholesterol, and other symptoms. By the age of 50, this decline can account for up to 40% less production compared to younger individuals.
This reduction primarily affects sleep but also impacts liver health, starting with weakened protection against potential liver cancer or various intestinal diseases. Consequently, if the liver becomes compromised, it can result in a circadian rhythm imbalance. Addressing these risks early is key to prevention.
The Benefits of Melatonin for Liver Health
In a completely different context, linking nutraceutical supplementation with melatonin and liver health, various studies highlight its immediate and beneficial effects.
As shown in this August 2020 study, researchers evaluated the effects of melatonin supplementation on key biochemical markers associated with the pathogenesis of non-alcoholic fatty liver disease. This randomized, double-blind clinical trial involved 24 participants in the melatonin group and 21 in the placebo group. Participants received 6 mg of melatonin or a placebo daily, one hour before bedtime. A few weeks into the study, scientists observed a significant improvement in numerous liver-related factors.
Another study, conducted in 2018 by Italian researchers, explored whether dietary melatonin supplementation could serve as a promising preventive or therapeutic approach for various liver diseases. To investigate this, they conducted a comprehensive meta-analysis, reviewing nearly 237 scientific references. The gathered studies suggested that increasing blood melatonin levels through diet might be considered a promising preventive strategy for a range of liver conditions.
+ Useful for cases of insomnia, trouble falling asleep, reducing time to fall asleep (from 1g), nighttime awakenings, and easing the effects of jet lag (from 0.5mg),
+ Sublingual form: 1.8 times better absorption than capsules and faster action: 85% of powdered melatonin does not enter the bloodstream,
+ 50 mL bottle. Duration: 160 days at 1.9mg/day (maximum recommended dose). Vegan
Melatonin’s Role in Cardiovascular Health
As noted earlier, melatonin’s effects extend beyond sleep and include significant benefits for liver health. But that’s not all—it also positively impacts the cardiovascular system, including the heart. However, inadequate melatonin secretion can pose risks to the body.
Numerous studies, including one from 2017, have found a correlation between low melatonin levels and an increased risk of cardiovascular diseases, such as coronary artery disease, hypertension, and heart failure. There is also a close relationship between melatonin and blood pressure regulation. A 2005 study demonstrated low serum melatonin levels in hypertensive patients.
The Benefits of Melatonin for Heart Health
When melatonin levels are naturally optimal or supported by supplementation, the body experiences numerous benefits. As highlighted in this June 2022 study, there is strong evidence of melatonin's advantages in addressing cardiovascular diseases, including:
- Protective effects against cardiotoxicity
- Cardiac regeneration
- Prevention of myocardial damage
- Cardiovascular system protection
- Antiproliferative, antifibrotic, and antihypertensive properties
- Anti-arrhythmic actions
- Protection against septic cardiomyopathy
- And more...
Another noteworthy study focuses on heart failure, an increasing concern in aging populations worldwide. Melatonin shows promise as a protective agent against myocardial loss in acute myocardial infarction, thereby helping to prevent heart failure. This potential is supported by findings in this 2014 study, which demonstrated that melatonin can lower blood pressure and reduce left ventricular remodeling.
In conclusion, the cardiovascular benefits of melatonin appear to stem from its metabolic influence, particularly its impact on lipids, glucose, and blood pressure.
Which Natural Alternatives Support Heart, Liver, and Sleep Health?
To effectively meet the body's needs and support it against various daily ailments (insomnia, cardiovascular issues, digestive problems, aging, etc.), several options are available. Among them are nutraceuticals, a natural health and wellness solution that combines multiple high-quality active ingredients in a single product.
Continuing the themes mentioned above, here are some dietary supplements from Solage Laboratories related to the liver, heart, and sleep:
- Heart: To enhance cardiovascular health, support brain function, and maintain good vision, it may be beneficial to supplement with Omega-3. Developed from pure krill oil (zooplankton), Solakrill is an eco-friendly product rich in Omega-3 DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) with excellent bioavailability. Another heart-friendly option is a supplement made from Kaneka Ubiquinol, a powerful antioxidant with anti-aging cellular benefits. Solquinol naturally helps reduce fatigue and supports the heart and blood vessels.
- Liver: Our lifestyle and diet often take a toll on the liver. It is crucial to support, detoxify, and protect this vital organ to avoid negative consequences. Using a natural plant like milk thistle in supplement form can be a wise choice. Solage Laboratories’ Solmarie, crafted from this beneficial plant, actively supports the liver by promoting detoxification and regeneration. Thanks to the patented milk thistle phytosome process, Solmarie offers five times higher absorption and comprehensive action.
- Sleep: For some individuals, insomnia or nighttime awakenings become a daily struggle. Helping the body avoid excessive fatigue is essential. This is where Solmeil, a sublingual liquid melatonin, comes in. It synchronizes the circadian rhythm, reduces the time to fall asleep, and improves sleep quality. Its unique sublingual form ensures 1.8 times better absorption than capsules and faster action. Additionally, 85% of powdered melatonin fails to enter the bloodstream. For others, stress and anxiety disrupt sleep quality and the ability to fall asleep. In such cases, Solazen, made from sublingual GABA (gamma-aminobutyric acid), Rhodiola Rosea, Scutellaria Baicalensis, and Vitamin B6, is a great option. Solazen has a calming effect, quickly reducing anxiety and promoting restful sleep.
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- Piril Hepsomali,John A. Groeger, Jun Nishihira, Andrew Scholey - Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review - Neuroenergetics, Nutrition and Brain Health - 17 September 2020.
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