Collagen Mix - 8 Bioactive Nutrients

Why choose Collagen Mix over other collagen supplements?

⇒ A cost-effective formula with 8 carefully dosed nutrients.

⇒ Simple and easy to use with its water-soluble powder that’s easy to measure and mix in a glass of water.

⇒ Patented collagen made in France with low molecular weight (3000 Da) for optimal absorption. The collagen peptides come from fish skin.

⇒ Patented organic silicon with superior absorption, demonstrated through studies.

⇒ Ultra-pure hyaluronic acid in the form of sodium hyaluronate for better absorption.

⇒ Alkalizing action (to combat acidity in the body) thanks to magnesium citrate and calcium carbonate.

⇒ Bone remineralization supported by the combination of calcium, magnesium, vitamin D3, and vitamin K2-MK7.

⇒ The effect of organic silicon on the body helps to slow down aging.

⇒ Among the many bioactives in Collagen Mix, type 1 collagen stands out. This collagen is found in most parts of the body and helps form the human skeletal structure.

⇒ Vitamin C aids in collagen production.

⇒ D3 supports calcium binding to bones. Additionally, it contributes to proper skeletal, joint, and dental mineralization.

⇒ With good bioavailability, as found in Collagen Mix, calcium fully supports bone health.

⇒ Hyaluronic acid, abundant in the body, supports moisture levels and aids in skin tissue repair.

⇒ Hyaluronic acid helps reduce skin aging.

⇒ Collagen Mix features a vanilla flavor, pleasant to the taste.

Collagen Mix Composition per 10g Serving:

• Marine Collagen Peptides - 7.46g
• Magnesium Citrate - 89.5mg
• Hyaluronic Acid (Sodium Hyaluronate) - 167mg
• Organic Silicon - 15mg (maltodextrin 95%, silicic acid 5%)
• Vitamin C - 133mg
• Vitamin K2-MK7 - 75μg
• Calcium Carbonate - 109mg
• Vitamin D3 - 5μg
• Stevia
• Flavor (vanilla)
• No excipients

Usage Precautions: Vitamin K supplementation is not recommended for those on anticoagulant therapy. Not suitable for children under 3 years old.

Initial Dose: 10 grams per day

Maintenance Dose: 5 grams per day

Instructions for Use: Mix 1 to 2 teaspoons (5 to 10 g) of powder in a glass of water.

Stir until dissolved, then consume. Collagen dissolves more easily in warm or hot liquid (its properties are not affected by heat).

When to Use Collagen Mix:

• Supports the health of bones, teeth, cartilage, gums, and skin.
• Helps protect cells from damage caused by free radicals.
• Provides joint support.
• Contributes to skin firmness and elasticity.
• Aids the proper functioning of skeletal muscles during regular physical activity, exercise, or sports.
• Enhances mobility.
• Supports the body in its regenerative actions on bones, cartilage, teeth, nails, hair, and more.

Important Information and Possible Side Effects:

• The Collagen complex is a dietary supplement and should not replace a varied and balanced diet or a healthy lifestyle.
• No known side effects at the recommended dosage.
• Store Collagen Mix in a cool, dry place, away from moisture.
• The collagen complex can be taken long-term for continuous benefits.
• If pregnant or breastfeeding, consult your doctor beforehand.
• Keep out of reach of children.

Enhanced Scientific Analyses and Information on 5 Key Active Ingredients in Collagen Mix:

Marine Collagen Peptides (Type 1 Collagen)

A natural biological process, aging is driven by a complex interplay of genetic and environmental factors. In the skin, it manifests as a gradual decline in collagen and elastin levels—two essential proteins that maintain skin health by ensuring firmness, elasticity, and structure.

As these proteins diminish, the skin becomes less flexible, loses its ability to retain elasticity, and begins to form wrinkles and fine lines. While the aging process itself cannot be completely halted, it can be slowed down and effectively managed—particularly through regular intake of nutraceutical marine collagen. (20)

Over the years, numerous studies have been conducted to support the efficacy of marine collagen peptides. Here are some key findings:

• A 2019 study published in Biosci Biotechnol Biochimie aimed to evaluate the effects of daily collagen peptide intake on skin damage. Specifically, the study assessed whether a consistent dosage of collagen peptides (0.2 g/kg/day) could counteract reduced skin hydration, epidermal hyperplasia, and decreased type I collagen levels. After several weeks, results suggested that collagen peptides are beneficial as a dietary supplement in mitigating UV-B-induced skin damage and photoaging. (21)

• A 2014 review, also published in Biosci Biotechnol Biochimie, explored the relationship between collagen peptides and vitamin C, along with their combined effects on skin health. The findings demonstrated that age-related skin degradation is closely linked to declining collagen levels. The study further suggested that co-treatment with collagen peptides (CP) and vitamin C (VC) is effective in managing age-related skin conditions. (22)

• A systematic review conducted in October 2021 focused on “the effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise.” This meta-analysis screened 856 articles and selected around 15 randomized controlled trials. The findings indicated that collagen peptides (COL) are most effective in improving joint function and reducing joint pain. Additional benefits included enhanced joint strength, more stable body composition, and improved muscle recovery. However, while collagen synthesis rates increased with a daily intake of 15 g of collagen peptides, there was no significant impact on muscle protein synthesis (MPS) compared to higher-quality iso-nitrogenous protein sources. (23)

Magnesium Citrate

With superior solubility and bioavailability compared to any other magnesium compound (24), magnesium citrate offers exceptional absorption, actively enhancing the body's interaction with magnesium.

Several studies have been conducted to demonstrate its superior bioavailability. One of the earliest was a clinical trial from the 1990s comparing magnesium citrate to magnesium oxide (25). Magnesium absorption from both forms was measured in vivo in healthy volunteers by assessing the increase in urinary magnesium levels following oral intake. The urinary magnesium increase after a 25 mmol magnesium citrate dose was significantly higher than that observed with magnesium oxide (during the first four hours post-intake: 0.22 vs. 0.006 mg/mg creatinine, p < 0.05; during the second two-hour period: 0.035 vs. 0.008 mg/mg creatinine, p < 0.05).

Magnesium is an essential mineral in the human body, required for numerous physiological functions. However, magnesium deficiencies are widespread, largely due to the declining nutrient content of foods. Overcooking, certain medical conditions, medications, alcohol consumption, and excessive caffeine intake further contribute to this issue.

Supplementing with magnesium, especially in the form of magnesium citrate, can be beneficial to improve absorption and maximize its active effects. According to a 2019 study (26), magnesium citrate helps increase magnesium levels in both muscles and the brain.

Hyaluronic Acid

A key component of the skin's extracellular matrix, hyaluronic acid plays a crucial role in various wound healing mechanisms. Naturally present in different tissues such as connective tissue, cartilage, joints, skin, and eyes, its levels gradually decrease with age.

Multiple studies have highlighted its numerous benefits for the human body:

• Wound Healing (27): In general, the normal wound healing process consists of three key phases: inflammatory, proliferative, and remodeling. Hyaluronic acid actively contributes to each stage, promoting stable, rapid, and optimal healing.

• Inflammatory Skin and Joint Diseases (28): A comprehensive review found that HA-based formulations have demonstrated remarkable efficacy in treating a wide range of inflammatory skin conditions. The study also reported that patients treated with hyaluronic acid showed significant improvements in chondrocyte density, territorial matrix appearance, restoration of the superficial amorphous cartilage layer, collagen remodeling, and meniscus regeneration. The researchers concluded: "In conclusion, we confirm that the application/administration of HA is a promising pharmacotherapeutic approach for the treatment of inflammatory skin and joint diseases."

• Skin Benefits and Anti-Aging Properties (29): Hyaluronic acid plays a multifaceted role in the body and was the subject of a 2018 scientific review. After extensive analysis, researchers concluded that HA has promising effects on skin tightening and elasticity, facial rejuvenation, improved aesthetic scores, wrinkle scar reduction, and enhanced longevity and regeneration of skin tears.

Organic Silicon

Essential for connective tissue health, organic silicon is one of the most well-known forms of silicon. It plays a crucial role in skin and hair care, as demonstrated by a 2016 study (30).

In another study from 2017, scientist Piet Geusens and his team highlighted the positive impact of this trace element on joint diseases (31). Their research was conducted through a multicenter, double-blind, placebo-controlled study involving 211 patients suffering from knee joint diseases and moderate to moderately severe pain. After 12 weeks of treatment, the results showed effectiveness in men, significantly reducing knee joint disease symptoms. Additionally, it was associated with a slight but meaningful decrease in biomarkers linked to cartilage degradation.

Lastly, a 2005 study (32) confirmed that oral intake of organic silicon positively impacts nail and hair quality, as well as sun-damaged skin. To validate this, researchers conducted a randomized, double-blind, placebo-controlled study with 50 women presenting photo-damaged facial skin. Over 20 weeks, they received 10 mg of Si/day in the form of ch-OSA lozenges (n = 25) or a placebo (n = 25). A few weeks later, nail and hair fragility had significantly decreased in the non-placebo group, demonstrating the reliability of silicon supplementation.

Calcium Carbonate

Calcium carbonate (CaCO3) is a chemical compound composed of three main elements: carbon, oxygen, and calcium. This substance is widely found in nature, forming part of marine organism shells, snails, coal balls, pearls, and eggshells (33).

This inorganic salt is classified as a calcium supplement, an antacid, and a phosphate binder—phosphorus being the second most abundant mineral in the human body after magnesium. As such, calcium carbonate plays a vital role in the body, particularly in addressing various bone diseases associated with decreased serum calcium levels (34).

The benefits of calcium supplementation were demonstrated in a 2022 study that aimed to analyze the effects of calcium carbonate preparations on malnutrition in preschool children. The study involved 100 malnourished preschool-aged children treated in a hospital between February 2020 and February 2021. The children were closely monitored, with outcome measures including bone content, malnutrition symptom scores, nutritional indices, urinary calcium levels, patient progress, and treatment satisfaction.

The study's initial results found that “after treatment, the calcium carbonate preparation group exhibited higher right heel bone content and bone density compared to the calcium lactate preparation group (P < 0.05).”

References:

1. Sarah Geahchan - Parnian Baharlouei et Azizur Rahman - Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration - Mar Drugs. 2022 Jan; 20(1): 61.
2. Malkanthi Evans DVM, PhD, Erin D. Lewis PhD, Nisrine Zakaria PhD, Tetyana Pelipyagina MD, Najla Guthrie BSc - A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity - Journal of Cosmetic Dermatology - 2020 ; Volume 20, Issue 3 p. 825-834
3. Mariangela Rondanelli, Milena Anna Faliva, Alice Tartara, Clara Gasparri, Simone Perna, Vittoria Infantino, Antonella Riva, Giovanna Petrangolini, Gabriella Peroni - An update on magnesium and bone health - Biometals - 2021 Aug ; 34(4):715-736. 
4. Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan - Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial - The American Journal of Clinical Nutrition - December 2018 ; Volume 108, Issue 6, Pages 1249–1258. 
5. Eleni Papakonstantinou, Michael Roth and George Karakiulakis - Hyaluronic acid : A key molecule in skin aging - Dermatoendocrinol - 2012 Jul 1 ; 4(3): 253–258.
6. Oe M, Sakai S, Yoshida H, Okado N, Kaneda H, Masuda Y, Urushibata - Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period - Clinical, Cosmetic and Investigational Dermatology - 2017 ; Volume 10, Pages 267-273.
7. Jing-Jin Yang and Xiu-Mei Zhang - Clinical Efficacy of Glucosamine plus Sodium Hyaluronate for Osteoporosis Complicated by Knee Osteoarthritis and Its Influence on Joint Function and Bone Metabolic Markers - Machine Learning and AI Methods in Computer Vision and Visualisation for Healthcare 2022 - Volume 2022.
8. Angelo Cagnacci, Dionisio Franco Barattini, Elena Casolati, Alberto Pecoroni, Mario Mangrella - Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausal transition: A prospective randomized trial - EJOG - MARCH 01 2022 ; VOLUME 270, P239-245.
9. W. Ibraheem, W.H. Jedaiba, A.M. Alnami, L.A. Hussain Baiti, S.M. Ali Manqari, A. Bhati, A. Almarghlani, M. Assaggaf - Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study - Eur Rev Med Pharmacol Sci - 2022 ; 26 (10): 3444-34493
10. N. Boqué, R. M. Valls,  A. Pedret, F. Puiggrós, L. Arola and R. Solà - Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study - Sci Rep. 2021 ; 11: 16479.
11. R. JUGDAOHSINGH - SILICON AND BONE HEALTH - J Nutr Health Aging - 2007 Mar-Apr ; 11(2): 99–110.
12. Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds - Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids - Washington (DC): National Academies Press (US) ; 2000.
13. Toshiro Sato, Naoko Inaba, and Takatoshi Yamashita - MK-7 and Its Effects on Bone Quality and Strength - Nutrients. 2020 Apr; 12(4): 965.
14. Naoko Inaba, Toshiro Sato, Takatoshi Yamashite - Low-Dose Daily Intake of Vitamin K2 (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials - 2015 Volume 61 Issue 6 Pages 471-480 
15. Michał Karpiński, Janusz Popko, Katarzyna Maresz, Vladimir Badmaev, Sidney J Stohs - Roles of Vitamins D and K, Nutrition, and Lifestyle in Low-Energy Bone Fractures in Children and Young Adults - J Am Coll Nutr - 2017 Jul ; 36(5):399-412.
16. J Iwamoto 1, T Takeda, S Ichimura - Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis - J Orthop Sci - 2000 ;5(6):546-51
17. Robert Y. van der Velde, Jacobus R. B. J. Brouwers, Piet P. Geusens, Willem F. Lems and Joop P. W. van den Bergh - Calcium and vitamin D supplementation: state of the art for daily practice - Food Nutr Res - 2014 ; 58: 10.
18. Sarah M Bristow, Greg D Gamble, Angela Stewart, Anne M Horne, Ian R Reid - Acute effects of calcium supplements on blood pressure and blood coagulation: secondary analysis of a randomised controlled trial in post-menopausal women - Br J Nutr - 2015 Dec 14 ;114(11):1868-74.
19. Jay R. Hoffman, Tavor Ben-Zeev, Amit Zamir, Chagai Levi, and Ishay Ostfeld - Examination of Amorphous Calcium Carbonate on the Inflammatory and Muscle Damage Response in Experienced Resistance Trained Individuals - Nutrients - 2022 May ; 14(9): 1894.
20. Licia Genovese & Sara Sibilla - Innovative Nutraceutical Approaches to Counteract the Signs of Aging - Textbook of Aging Skin - 2016 ; 1967–1991
21. Midori Tanaka, Yoh-ichi Koyama, Yoshihiro Nomura - Effects of collagen peptide ingestion on UV-B-induced skin damage - Biosci Biotechnol Biochem - 2009 Apr 23 ; 73(4):930-2.
22. Shuichi Shibuya, Yusuke Ozawa, Toshihiko Toda, Kenji Watanabe, Chisa Tometsuka, Takayuki Ogura, Yoh-ichi Koyama, Takahiko Shimizu - Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice - Biosci Biotechnol Biochem - 2014 ; 78(7):1212-20
23. Mishti Khatri, Robert J Naughton, Tom Clifford, Liam D Harper, Liam Corr - The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review - Amino Acids - 2021 Oct ; 53(10):1493-1506
24. Jennifer Roth - Le magnésium, minéral incontournable ? : enquête auprès des patients de l’officine - HAL open science - 2017
25. J S Lindberg 1, M M Zobitz, J R Poindexter, C Y Pak - Magnesium bioavailability from magnesium citrate and magnesium oxide - J Am Coll Nutr - 1990 Feb ; 9(1):48-55.
26. Mehmet Ates, Servet Kizildag, Oguz Yuksel, Ferda Hosgorler, Zeynep Yuce, Guven Guvendi, Sevim Kandis, Aslı Karakilic, Basar Koc, Nazan Uysal - Dose-Dependent Absorption Profile of Different Magnesium Compounds - Biol Trace Elem Res - 2019 Dec ; 192(2):244-251.
27. Joseph S Frenke - The role of hyaluronan in wound healing -  International Wound Journal - 2012 - Volume 11, Issue 2 p. 159-163
28. Li Hui Chen, Jian Feng Xue, Zhi Yong Zheng, Muhammad Shuhaidi, Hnin Ei Thu, Zahid Hussain - Hyaluronic acid, an efficient biomacromolecule for treatment of inflammatory skin and joint diseases: A review of recent developments and critical appraisal of preclinical and clinical investigations - Int J Biol Macromol -2018 Sep ; 116:572-584
29. Syed Nasir Abbas Bukhari, Nur Liyana Roswandi, Muhammad Waqas, Haroon Habib, Fahad Hussain, Shahzeb Khan, Muhammad Sohail, Nor Amlizan Ramli, Hnin Ei Thu, Zahid Hussain - Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects - Int J Biol Macromol - 2018 Dec ; 120 (Pt B) :1682-1695
30. Use of silicon for skin and hair care: an approach of chemical forms available and efficacy - Lidiane Advincula de Araújo, Flavia Addor and Patrícia Maria Berardo Gonçalves Maia Campos - An Bras Dermatol - 2016 May-Jun ; 91(3): 331–335
31. A Barel, M Calomme, A Timchenko, K De Paepe, N Demeester, V Rogiers, P Clarys, D Vanden Berghe - Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin - Arch Dermatol Res - 2005 Oct ; 297(4):147-53.
32. A Barel, M Calomme, A Timchenko, K De Paepe, N Demeester, V Rogiers, P Clarys, D Vanden Berghe - Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin - Arch Dermatol Res - 2005 Oct ; 297(4):147-53.
33. MMH Al Omari, EST Rachid, NA Qinna, AM Jaber, AA Badouan - Calcium carbonate - Profils Drug Subst Excip Relat Methodol - 2016 ; 41:31-132
34. Kristina Fritz; Katherine Taylor; Mayur Parmar -Calcium Carbonate -  StatPearls Publishing ; 2022 Jan-