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Pure bromelain - 5000 GDU/g - Somelain
€29.61
€32.90
DLUO : 28/04/26
Shipped on : 20 January 2025
+ Pure Bromelain (enzyme complex) with 5000 GDU/g from pineapple stem. Obtained through water extraction, solvent-free.
+ 100% natural, gastro-resistant vegetable capsules to protect Bromelain from gastric juices.
+ Box of 60 vegan capsules. Duration: 30 days for maintenance doses. No excipients, no preservatives. Made in France (Brittany).
Bromelain: A Virtuous Enzyme Alliance
Derived from the pineapple stem, bromelain, named after "bromeliaceae" (the botanical family of pineapple), is a natural enzyme blend that, unlike other enzymes, is well absorbed and retains high bioavailability (enzymatic activity). (1)
At the core of bromelain are no fewer than 8 proteolytic enzymes (including thiol endo-peptidases, phosphatases, glucosidases, peroxidases, cellulases, glycoproteins...), along with various other components such as flavonoids, sterols, and fatty acids.
The bromelain found in pineapple is a type of enzyme known as a protease, which breaks down other proteins by cutting amino acid chains. Specifically, bromelain is a cysteine protease, meaning it breaks down proteins containing the amino acid cysteine.
For centuries, pineapple and its bromelain have been used in traditional South American medicine to promote optimal well-being. Bromelain has been studied for its effects on the intestines, blood vessels, the immune system, body weight, and fat cells.
Three Unique Qualities in a 100% Natural Extract
High-quality bromelain requires exceptional raw materials (pineapples). To ensure this, Solage Laboratories collaborates with small-scale farms run by trusted farmers fully committed to environmental sustainability.
For sustainable and eco-friendly pineapple cultivation, farmers prioritize two major principles: manual weeding, avoiding chemicals, and natural irrigation, with no waste of their farmland resources.
Good to know: Pineapples need at least 24 months (two years) to reach perfect harvesting conditions.
Pure and High-Quality Extraction Technology
Long considered waste, the pineapple stem, like fresh fruit, is rich in bromelain. To obtain a concentrated, ultra-pure extract free from toxicity, bromelain must be extracted using a specific method. (2)
This extraction process combines water extraction with advanced filtration techniques, including various decanting, microfiltration, sterile filtration, and ultrafiltration stages to yield a 100% natural, pure bromelain, free of toxicity and waste.
Good to know: Highly pure and qualitative, producing 1 kg of pure bromelain requires nearly 85 kg of pineapple stems.
An Enzymatic Activity Over 5000 GDU/G
This pure, qualitative, and eco-responsible bromelain extraction yields a fully natural native structure. Simply put, each batch is checked to ensure a standardization above 5000 GDU/g, the highest level of enzymatic purity available.
Good to know: The GDU (Gelatin Digestive Unit) is a specialized scientific method for measuring bromelain absorption. The GDU test assesses the digestive yield of gelatin in contact with 1 gram of bromelain. (3)
Gastro-Resistant Plant-Based Capsule (HPMC)
Orally, much of the bromelain, often packaged in standard capsules, is destroyed by digestive substances, reducing effectiveness.
To counter this, our Bromelain is protected in a gastro-resistant plant-based capsule.
This innovative technology, BIO-compliant, fully shields proteolytic enzymes from degradation until they can fulfill their purpose.
Additionally, the gastro-resistant capsule contains no varnishes, chemicals, or solvent residues, providing optimal protection against oxygen and moisture without compromising the active ingredient.
Packaged in France, specifically in Brittany, Somélaïne meets the highest quality standards and is ISO 9001 and FSSC 22000 certified.
Why choose Somelaine over other bromelain supplements?
⇒ Somelaine is a 100% French-made product, eco-friendly, with no excipients, GMOs, or nanoparticles.
⇒ The bromelain is extracted using a specialized aqueous extraction process (combining water extraction with advanced filtration).
⇒ This near-perfect extraction preserves the natural structure of bromelain and ensures a standardization of over 50,000 GDU per gram, the highest level of purity and effectiveness.
⇒ The bromelain in Solage Laboratories’ product is protected from oxygen and moisture by plant-based, gastro-resistant capsules. These capsules are free from solvent residues, varnishes, and chemicals.
⇒ The unique cultivation and extraction process of bromelain guarantees a 100% natural product. Additionally, continuous testing ensures production without pesticides, microbiological contaminants, polycyclic aromatic hydrocarbons, dioxins, heavy metals, organic solvents…
Daily Recommended Dose: Composition for Three Vegetable Capsules
- Bromelain (1500 mg = 7500 GDU) extracted from Pineapple Stem (Ananas comosus)
Take 1 to 3 capsules daily between meals (20 minutes before or 3 hours after). Swallow with a glass of water.
Consult a healthcare professional to determine the exact amount of Somelaine suited to your needs.
When to Use Somelaïne:
=> There are no claims officially authorized by current European legislation.
However, Bromelain has been the subject of scientific studies that can be accessed on several professional reference sites (such as PubMed). Below is a non-exhaustive list of areas in which Bromelain has been studied:
- Helps maintain the body’s natural defenses. (4)
- Promising effects on joint pain. (5)
- Contributes to maintaining natural blood fluidity and vascular permeability.
- Helps reduce the sensation of heavy legs.
- Anti-inflammatory action with specific effects on wound healing. (6)
- Anti-inflammatory effect to support overall health. (7)
- Platelet anti-aggregant activity beneficial for cardiovascular health.
- Antiseptic properties for wound cleaning.
- Supports the liver and intestinal system to aid digestion.
- Contributes to tissue drainage.
- Effects on cellulite.
Important Information and Possible Side Effects:
- Somelaïne is a dietary supplement and does not replace a varied, balanced diet and a healthy lifestyle.
- For ongoing benefits, Solage Laboratories’ bromelain can be taken over time.
- Store Somelaïne in a dry, cool place, away from humidity.
- Do not exceed the recommended daily dose.
- Keep out of reach of children.
- If you are allergic to pineapple, olive pollen, or bee stings, you may also be allergic to bromelain.
Bromelain, a major proteinase derived from pineapple (Ananas comosus), is primarily composed of a sulfhydryl proteolytic fraction. It also contains peroxidase, acid phosphatase, several protease inhibitors, and calcium. Bromelain comprises 212 amino acids, with a molecular weight of 33 kDa. (8)
Scientifically Studied Benefits
Inflammation
A complex biological mechanism, inflammation affects every living organism and can serve as a significant marker for the development of numerous serious diseases. Among bromelain's many beneficial actions, its anti-inflammatory effect is perhaps the most extensively studied.
This study highlights bromelain’s anti-inflammatory properties:
- Published in 2021, this study aimed to “assess the anti-inflammatory effects of bromelain after simulated gastrointestinal digestion in vitro using human cell models from the stomach, intestine, and chondrocytes.” (9) For this purpose, specific cytokines were used to induce inflammation in cell lines to evaluate bromelain’s effectiveness in reducing the inflammatory response.
- To reduce inflammation, the patients’ cell lines were treated with 35mg/L of bromelain. Initial results suggest that the anti-inflammatory properties of bromelain and its digested hydrolysates have a strong anti-inflammatory effect under all tested conditions.
- In conclusion, scientists believe that “bromelain is a promising candidate for the development of future oral enzyme therapies for treating acute and chronic inflammatory conditions, with the potential for fewer undesirable side effects commonly associated with anti-inflammatory drugs.”
Joint Pain
Joint diseases are widespread in the United States, significantly affecting the population. (10) In response to these issues, bromelain could be an effective solution due to its analgesic effects, which may stem from its direct impact on pain mediators.
A comparative study on several enzymes, including bromelain, was conducted to examine these effects:
- Published on July 24, 2004, this study primarily aimed to compare the efficacy and safety of an oral enzyme-rutoside combination (ERC) containing rutoside, bromelain, and trypsin enzymes with diclofenac in patients with knee osteoarthritis. (11)
- To achieve this, 103 patients with painful episodes of knee osteoarthritis were treated for six weeks in a randomized, double-blind, parallel-group trial. A total of 52 patients were treated in the ERC group, and 51 in the diclofenac group. Significant improvements were observed in both treatment groups over the six-week observation period, with a slight tendency toward the superiority of the ERC combination (including bromelain).
- In conclusion, scientists believe that “tolerance was rated as very good or good in both medication groups for most patients. The current study indicates that ERC (bromelain combination) can be considered an effective and safe alternative in treating painful episodes of knee osteoarthritis.”
Wound Healing
Wound healing, a tissue repair process encompassing three phases (inflammatory, healing, and epidermal remodeling), could be significantly enhanced by bromelain supplementation.
This study showcases bromelain's wound-healing effect in rats:
- Published in 2020, this study’s primary objective was “to evaluate bromelain's effect on various aspects of wound healing in type 1 diabetic rats.” (12)
- In this study, 112 male Wistar diabetic rats (type 1) were euthanized; 28 each on days three, five, seven, and fifteen after a wound incision. Bromelain caused significant wound contraction and reduced granulation tissue formation by day seven.
- In conclusion, scientists concluded that “based on the study's results, bromelain can be used as an effective health supplement to promote and accelerate wound healing, reduce inflammation, and improve biomechanical parameters in diabetic wounds.”
Blood Circulation and Blood Disorders
Highly active in blood coagulation and fibrinolysis (the enzymatic process of fibrin dissolution that can cause severe hemorrhages), bromelain has several notable effects on blood flow. (13) (14)
Skin Conditions
Bromelain has proven effective against melanoma and squamous cell carcinoma cell lines. This enzyme not only minimized their proliferation but also reduced COX-2 gene expression and suppressed metastases. (15) (16)
Anti-Cellulite
Due to its proteolytic activity, bromelain has been used in many industries (food, medical, pharmaceutical...), including cosmetics, where bromelain may positively impact cellulite. (17) (18)
With its anti-inflammatory effect, bromelain can reduce inflammation caused by cellulite’s fatty deposits. Bromelain also promotes fibrin dissolution (a protein involved in fat deposits). Additionally, its positive impact on blood circulation aids in eliminating toxins and waste in the body, helping to reduce cellulite formation. (19) (20)
Scientific References -
1. Bromelain: Biochemistry, Pharmacology, and Medical Use - H R Maurer - Cell Mol Life Sci - Aug 2001; 58(9):1234-45
2. Bromelain: Methods of Extraction, Purification, and Therapeutic Applications - Zoya Manzoor, Ali Nawaz, Hamid Mukhtar, Ikram Haq - Human and Animal Health - 2016; Braz. arch. biol. technol. 59
3. Gelatin Digestion Unit Analytical Method - Enzyme Development Corporation - (212) 736-1580
4. Panagiotis Kritis, Irene Karampela, Styliani Kokoris, Maria Dalamaga - The Combination of Bromelain and Curcumin as an Immune-Boosting Nutraceutical in COVID-19 Prevention - Metabolism Open - Volume 8, Dec 2020-100066
5. Sarah Brien, George Lewith, Ann Walker, Stephen M. Hicks, and Dick Middleton - Bromelain as a Treatment for Osteoarthritis: A Review of Clinical Studies - Evid Based Complement Alternat Med - Dec 2004; 1(3): 251–257.
6. Sara Soheilifar, Mohsen Bidgoli, Amirarsalan Hooshyarfard, Armaghan Shahbazi, Farshid Vahdatinia, Fahime Khoshkhooie - Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial - J Dent (Tehran) - Sep 2018; 15(5):309-316.
7. P- Vidhya Rathnavelu, Noorjahan Banu Alitheen, Subramaniam Sohila, Samikannu Kanagesan, Rajendran Ramesh - Potential Role of Bromelain in Clinical and Therapeutic Applications - Biomed Rep. Sep 2016; 5(3): 283–288.
8. P.DUPAIGNE - Biochemical Effects of Bromelains and Their Use in Therapy - Fruits - Sep 1975; vol. 30, no. 9, p. 545-567.
9. Roberta Bottega, Ilaria Persico, Giovanni Di Lorenzo - Anti-inflammatory Properties of a Proprietary Bromelain Extract (Bromeyal™) after In Vitro Simulated Gastrointestinal Digestion - International Journal of Immunopathology and Pharmacology - Jan-Dec 2021; Vol. 35
10. Reva C. Lawrence, Charles G. Helmick, Frank C. Arnett, Richard A. Deyo, David T. Felson, Edward H. Giannini, Stephen P. Heyse, Rosemarie Hirsch, Marc C. Hochberg, Gene G. Hunder - Estimates of Arthritis and Musculoskeletal Disorder Prevalence in the U.S. - Arthritis & Rheumatism - 2004; Volume 41, Issue 5, p. 778-799
11. Naseer M. Akhtar, Rizwan Naseer, Abid Z. Farooqi, Wajahat Aziz, Mussadeq Nazir - Oral Enzyme Combination vs. Diclofenac in Knee Osteoarthritis Treatment: A Double-Blind Randomized Study - Clinical Rheumatology - 2004; Volume 23, pages 410–415
12. Amene Nikgoftar Fathi, Mohammad Hassan Sakhaie, Sepehr Babaei, Soroush Babaei, Fateme Slimabad, Saeid Babaei - Use of bromelain in cutaneous wound healing in streptozocin-induced diabetic rats: an experimental model - J Wound Care - 2020 Sep 2;29(9):488-495.
13. Steven J. Taussig a, Stanley Batkin - Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update - Journal of Ethnopharmacology - February–March 1988 ; Volume 22, Issue 2, Pages 191-203
14.- Zia Uddin, Arkajyoti Paul, Ahmed Rakib, Saad Ahmed Sami, Shafi Mahmud, Sohel Rana, Shahadat Hossain, Abu Montakim Tareq, Mycal Dutta, ,Talha Bin Emran, Jesus Simal-Gandara -Chemical Profiles and Pharmacological Properties with in Silico Studies on Elatostema papillosum Wedd - Molecules ; 2021, 26(4), 809;
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FAQ (questions fréquentes)
- Most of our nutrients come from France or Europe (local is a priority), except when we can't do otherwise (for curcuma, for example). We never choose ingredients from places or countries where quality is not assured and workers are poorly paid.
- Solage products are designed in France and manufactured according to GMP (Good Manufacturing Practice) standards from the pharmaceutical industry and the HACCP (Hazard Analysis Critical Control Point) method, developed by NASA.
Both methods implement procedures, documents and controls to guarantee perfect traceability and the absence of biological or chemical contamination.
- Solage is a French company, and its products are registered with the relevant authorities.
Solage products are safe, with no bad surprises.
To answer this question, we distinguish between three types of product, depending on their nature and intended purpose:
1/ Ideally taken as a continuous treatment: those which compensate for a nutritional or age-related deficiency, and which serve to restore the body's functions without altering its normal metabolism.
- Common nutritional deficiencies: marine omega-3, vitamin C, magnesium, vitamin D between October and May
- Age-related or pathological deficiencies: Ubiquinol, Glutathione, Iron, Collagen (type I and II)
- To help the body deal with underlying problems: Saffron, Ashwagandha, Men's and women's urinary comfort, cholesterol
2/ To be taken in a cure, but where a break is not necessarily necessary if you or your healthcare professional find it useful:
Detox: Milk thistle, Glutathione
Digestion: Probiotics
3/ Products where a break is useful:
- Curcumin: at least a break of a few days between each box, as it modifies metabolic pathways in the body
- Echinacea (immunity): a break of a few days between each box so as not to over-stimulate the immune system
- Melatonin: avoid taking it every day over the long term, so as not to habituate the body.
In all cases, it's important to remember that the products we offer are genuinely active, that it's important to respect dosage and that they are not a substitute for a varied, balanced diet and a healthy lifestyle.
This will of course depend on the product and your physiological state.
It's worth remembering that physiology is a long-term process, and that it generally takes two to three months, sometimes longer, to achieve a profound change.
However, the feeling is generally quicker, between 15 days and two months.It is then necessary to continue to try to fix these initial results in greater depth.
However, this will be much quicker with subsequent products:
- Melatonin and sublingual GABA, which have a very rapid onset of action (between two minutes and 30 minutes)
- Probiotics (48 hours to two weeks))
Please refer to the “Scientific studies” section of this product page, where you'll find most studies on bioavailability and medium-term effects.
