Pure bromelain - 5000 GDU/g - Somelain

Why choose Somelaine over other bromelain supplements?

⇒ Somelaine is a 100% French-made product, eco-friendly, with no excipients, GMOs, or nanoparticles.

⇒ The bromelain is extracted using a specialized aqueous extraction process (combining water extraction with advanced filtration).

⇒ This near-perfect extraction preserves the natural structure of bromelain and ensures a standardization of over 50,000 GDU per gram, the highest level of purity and effectiveness.

⇒ The bromelain in Solage Laboratories’ product is protected from oxygen and moisture by plant-based, gastro-resistant capsules. These capsules are free from solvent residues, varnishes, and chemicals.

⇒ The unique cultivation and extraction process of bromelain guarantees a 100% natural product. Additionally, continuous testing ensures production without pesticides, microbiological contaminants, polycyclic aromatic hydrocarbons, dioxins, heavy metals, organic solvents…

Daily Recommended Dose: Composition for Three Vegetable Capsules

• Bromelain (1500 mg = 7500 GDU) extracted from Pineapple Stem (Ananas comosus)

Take 1 to 3 capsules daily between meals (20 minutes before or 3 hours after). Swallow with a glass of water.

Consult a healthcare professional to determine the exact amount of Somelaine suited to your needs.

When to Use Somelaïne:

=> There are no claims officially authorized by current European legislation.

However, Bromelain has been the subject of scientific studies that can be accessed on several professional reference sites (such as PubMed). Below is a non-exhaustive list of areas in which Bromelain has been studied:

• Helps maintain the body’s natural defenses. (4)
• Promising effects on joint pain. (5)
• Contributes to maintaining natural blood fluidity and vascular permeability.
• Helps reduce the sensation of heavy legs.
• Anti-inflammatory action with specific effects on wound healing. (6)
• Anti-inflammatory effect to support overall health. (7)
• Platelet anti-aggregant activity beneficial for cardiovascular health.
• Antiseptic properties for wound cleaning.
• Supports the liver and intestinal system to aid digestion.
• Contributes to tissue drainage.
• Effects on cellulite.

Important Information and Possible Side Effects:

• Somelaïne is a dietary supplement and does not replace a varied, balanced diet and a healthy lifestyle.
• For ongoing benefits, Solage Laboratories’ bromelain can be taken over time.
• Store Somelaïne in a dry, cool place, away from humidity.
• Do not exceed the recommended daily dose.
• Keep out of reach of children.
• If you are allergic to pineapple, olive pollen, or bee stings, you may also be allergic to bromelain.

A major protease isolated from pineapple (Ananas comosus), bromelain is primarily composed of a sulfhydryl proteolytic fraction. It also contains a peroxidase, an acid phosphatase, several protease inhibitors, and calcium. Bromelain consists of 212 amino acids and has a molecular weight of 33 kilodaltons. (8)

Scientifically Studied Notable Benefits

Inflammation

Inflammation is a complex biological mechanism that affects all living beings and can serve as a significant marker for the development of several serious diseases. Among bromelain’s numerous beneficial actions, its anti-inflammatory effect is undoubtedly the most extensively studied scientifically.

One study, in particular, aimed to demonstrate bromelain’s anti-inflammatory effect:

• Published in 2021, this study sought to "evaluate the anti-inflammatory effects of bromelain after simulated gastrointestinal digestion in vitro using human cell models of the stomach, intestine, and chondrocytes." (9) To achieve this, specific cytokines were used to stimulate the body’s cell lines, inducing inflammation and allowing researchers to assess bromelain’s ability to reduce the inflammatory response.

• To mitigate inflammation, patient cell lines were treated with 35 mg/L of bromelain. Initial results suggest that bromelain preparations and their digested hydrolysates exhibit strong anti-inflammatory effects under all tested conditions.

• In conclusion, the study’s scientists stated that "bromelain is a promising candidate for the development of future oral enzymatic therapies for the treatment of acute and chronic inflammatory conditions, with the potential for fewer undesirable side effects commonly associated with anti-inflammatory drugs."

Joint Pain

Widely prevalent in the United States, joint diseases significantly impact the American population (10). In response to these issues, bromelain could be an effective solution due to its analgesic properties, which are believed to stem from its direct effect on pain mediators.

To investigate these effects, a comparative study of several enzymes, including bromelain, was conducted:

• Published on July 24, 2004, the study aimed primarily to compare the efficacy and safety of an oral enzyme-rutoside combination (ERC) containing rutoside, bromelain, and trypsin enzymes against diclofenac in patients suffering from knee osteoarthritis (11).

• For this purpose, 103 patients experiencing painful episodes of knee osteoarthritis were treated over six weeks in a randomized, double-blind, parallel-group trial. A total of 52 patients received treatment in the ERC group, while 51 were treated with diclofenac. Both treatments led to significant improvements over the six-week observation period. Additionally, notable improvements were observed in secondary efficacy criteria, with a slight trend favoring the ERC (bromelain-containing combination).

• In conclusion, scientists stated that “for the majority of patients, tolerance was rated as very good or good in both treatment groups. The current study suggests that ERC (bromelain-containing combination) can be considered a safe and effective alternative for managing painful episodes of knee osteoarthritis.”

Scars and Open Wounds

The skin tissue repair process, which unfolds in three stages— the inflammatory phase, the healing phase, and the epidermal remodeling phase—could be significantly enhanced by bromelain supplementation.

This is supported by a study aimed at demonstrating bromelain's wound-healing effects in rats:

• Published in 2020, this scientific study primarily sought to “evaluate the effect of bromelain on different aspects of the healing process in type 1 diabetic rats.” (12)

• In this study, 112 male Wistar rats with streptozotocin-induced type 1 diabetes were euthanized—28 on days three, five, seven, and 15—after a wound incision was made. However, within the first few days, bromelain significantly contracted the wound and reduced granulation tissue formation by day 7.

• In conclusion, the researchers stated that “according to the findings of this study, bromelain can be used as an effective health supplement to promote and accelerate wound healing markers, reduce inflammation, and improve the biomechanical properties of diabetic wounds.”

Blood Circulation and Blood-Related Issues

Highly active in blood coagulation and fibrinolysis (an enzymatic process that dissolves fibrin and can lead to severe hemorrhages), bromelain has several notable effects on blood flow. (13) (14)

Skin Disease

Bromelain has been shown to be effective against melanoma and squamous cell carcinoma cell lines. This enzyme not only inhibited their proliferation but also reduced COX-2 gene expression and suppressed metastases. (15) (16)

Anti-Cellulite

Due to its proteolytic activity, bromelain has been widely used in various industries (food, medical, pharmaceutical…), including cosmetics, where it can have a beneficial effect on cellulite. (17) (18)

Thanks to its anti-inflammatory properties, bromelain can help reduce inflammation caused by fat deposits in cellulite. Additionally, bromelain promotes the breakdown of fibrin (a protein involved in fat deposit formation). Lastly, its positive effect on blood circulation helps eliminate toxins and waste from the body, which contributes to reducing cellulite formation. (19) (20)

Scientific References -

1. Bromelain: Biochemistry, Pharmacology, and Medical Use - H R Maurer - Cell Mol Life Sci - Aug 2001; 58(9):1234-45

2. Bromelain: Methods of Extraction, Purification, and Therapeutic Applications - Zoya Manzoor, Ali Nawaz, Hamid Mukhtar, Ikram Haq - Human and Animal Health - 2016; Braz. arch. biol. technol. 59

3. Gelatin Digestion Unit Analytical Method - Enzyme Development Corporation - (212) 736-1580

4. Panagiotis Kritis, Irene Karampela, Styliani Kokoris, Maria Dalamaga - The Combination of Bromelain and Curcumin as an Immune-Boosting Nutraceutical in COVID-19 Prevention - Metabolism Open - Volume 8, Dec 2020-100066

5. Sarah Brien, George Lewith, Ann Walker, Stephen M. Hicks, and Dick Middleton - Bromelain as a Treatment for Osteoarthritis: A Review of Clinical Studies - Evid Based Complement Alternat Med - Dec 2004; 1(3): 251–257.

6. Sara Soheilifar, Mohsen Bidgoli, Amirarsalan Hooshyarfard, Armaghan Shahbazi, Farshid Vahdatinia, Fahime Khoshkhooie - Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial - J Dent (Tehran) - Sep 2018; 15(5):309-316.

7. P- Vidhya Rathnavelu, Noorjahan Banu Alitheen, Subramaniam Sohila, Samikannu Kanagesan, Rajendran Ramesh - Potential Role of Bromelain in Clinical and Therapeutic Applications - Biomed Rep. Sep 2016; 5(3): 283–288.

8. P.DUPAIGNE - Biochemical Effects of Bromelains and Their Use in Therapy - Fruits - Sep 1975; vol. 30, no. 9, p. 545-567.

9. Roberta Bottega, Ilaria Persico, Giovanni Di Lorenzo - Anti-inflammatory Properties of a Proprietary Bromelain Extract (Bromeyal™) after In Vitro Simulated Gastrointestinal Digestion - International Journal of Immunopathology and Pharmacology - Jan-Dec 2021; Vol. 35

10. Reva C. Lawrence, Charles G. Helmick, Frank C. Arnett, Richard A. Deyo, David T. Felson, Edward H. Giannini, Stephen P. Heyse, Rosemarie Hirsch, Marc C. Hochberg, Gene G. Hunder - Estimates of Arthritis and Musculoskeletal Disorder Prevalence in the U.S. - Arthritis & Rheumatism - 2004; Volume 41, Issue 5, p. 778-799

11. Naseer M. Akhtar, Rizwan Naseer, Abid Z. Farooqi, Wajahat Aziz, Mussadeq Nazir - Oral Enzyme Combination vs. Diclofenac in Knee Osteoarthritis Treatment: A Double-Blind Randomized Study - Clinical Rheumatology - 2004; Volume 23, pages 410–415

12. Amene Nikgoftar Fathi, Mohammad Hassan Sakhaie, Sepehr Babaei, Soroush Babaei, Fateme Slimabad, Saeid Babaei - Use of bromelain in cutaneous wound healing in streptozocin-induced diabetic rats: an experimental model - J Wound Care - 2020 Sep 2;29(9):488-495. 

13. Steven J. Taussig a, Stanley Batkin - Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update - Journal of Ethnopharmacology - February–March 1988 ; Volume 22, Issue 2, Pages 191-203

14.- Zia Uddin, Arkajyoti Paul, Ahmed Rakib, Saad Ahmed Sami, Shafi Mahmud, Sohel Rana, Shahadat Hossain, Abu Montakim Tareq, Mycal Dutta, ,Talha Bin Emran, Jesus Simal-Gandara -Chemical Profiles and Pharmacological Properties with in Silico Studies on Elatostema papillosum Wedd -  Molecules ; 2021, 26(4), 809;