Cholesterol Support: Black Garlic, Olive Fruit and Leaves - Solesterol
+ Ultra-concentrated black garlic extract (ABG 25) standardized to 0.5 mg of S-allyl-cysteine: helps maintain healthy heart function, cholesterol, and homocysteine levels.
+ Olive polyphenols, including hydroxytyrosol (from the fruit) and oleuropein (from the leaves), support stable cholesterol levels, healthy blood circulation, and vascular pressure.
+ 60-capsule bottle. Lasts 1 to 2 months (1 or 2 capsules per day). Vegan. Free of excipients.
A Concentration of the Mediterranean Diet in a Capsule of Patented, Ultra-Concentrated Actives to Naturally Regulate Cholesterol
In France, nearly 20% of the population has a cholesterol level above normal.
High cholesterol is the cause of one in two heart attacks. However, natural, safe regulation without side effects (unlike statins) is possible.
Good Cholesterol and Bad Cholesterol
It’s essential to distinguish between the two main types of blood cholesterol:
"Good" cholesterol, also known as HDL cholesterol (high-density lipoprotein), works to collect molecules deposited in the arteries and guide them to the liver. Simply put, HDL cholesterol removes excess "bad" cholesterol so it can be eliminated.
A cholesterol level is generally considered "average" when it falls between 0.4 g/L - 0.6 g/L in adult men and 0.5 g/L - 0.6 g/L in adult women.
The second type, known as "bad" cholesterol or LDL cholesterol (low-density lipoprotein), comprises those infamous molecules that accumulate in the arteries.
LDL cholesterol eventually leads to atherosclerotic plaque buildup (fat deposits) on the inner artery walls. This buildup obstructs proper blood flow (especially for red blood cells) and increases the risk of cardiovascular issues.
An LDL cholesterol level is generally considered normal when it’s between 0.9 and 1.6 g/L in adults.
Solesterol: What Exactly Is It?
Solesterol is a unique combination of natural actives. This carefully dosed blend primarily aims to support healthy heart and artery function, all while naturally and safely regulating the patient's cholesterol level.
It’s the perfect marriage of Japanese tradition and the Mediterranean diet, optimized by scientific extraction and purification techniques.
- ABG 25: a patented fermented black garlic extract with unmatched effectiveness thanks to its exceptional standardization at 2.5% S-allyl-cysteine. Black garlic, often used in cardiovascular and digestive issues, is a natural cholesterol-lowering agent widely used in Japan.
- Two complementary olive extracts: leaf and fruit (olive). This plant, a symbol of longevity, is abundant in southern Europe and offers numerous nutritional, metabolic, and cardiovascular benefits.
- A triad of three B vitamins (B6, B9, and B12) with a crucial role in cellular metabolism. These B vitamins support various aspects of health, including immunity, reduced fatigue, hormone regulation, blood cell formation, and nervous system function.
The Actives in Solesterol
Patented Fermented Black Garlic AG25: Enhanced Benefits Without the Drawbacks
This Japanese or Korean aging technique transforms garlic into a new food.
Starting from fresh garlic aged in clay pots, the garlic transforms both physically and chemically.
Initially, the level of allicin, which gives garlic its strong odor, decreases.
As fermentation continues, new compounds appear, including flavonoids, polyphenols, S-allyl mercapto cysteine, and the famous S-allylcysteine.
These compounds are renowned for their unique health benefits.
Flavonoids:
- Act as natural antioxidants
- Help reduce oxidative stress
- Reduce aging effects
- Protect cells
- Enhance antioxidant defense systems
Polyphenols:
- Reduce oxidized lipids on artery surfaces
- Antioxidant
- Help control excess cholesterol
S-allylcysteine:
- Reduces cholesterol
- Prevents neuron death
Ordinary garlic cloves are transformed into a ‘superfood’ with multiple benefits:
- Maintains normal cholesterol levels
- High antioxidant properties
- Supports heart health
- Contributes to healthy liver function
- Boosts resistance against temporary stress
- Supports a normal immune function
- May help moderate high blood pressure
The benefits of aged fermented black garlic are scientifically proven. Numerous studies have validated its effectiveness, including:
The first study, conducted in Japan, investigated the endothelium (cell layer lining blood vessels) of rats.
This study showed that black garlic intake relaxed blood vessels (by releasing nitric oxide). Thus, black garlic may help in nutritional management of hypertension.
The second study, conducted in Spain, examined the effects of black garlic extract on rats fed a high-fat, high-sugar diet.
Treated animals showed lower body weight, triglycerides, and LDL cholesterol levels, reduced plasma insulin and leptin, and higher adiponectin levels, which protect against metabolic syndrome.
Olive Leaf and Fruit
Second and third actives in Solesterol: olive leaf and fruit.
A true nutritional model, the olive (Olea europaea) thrives in warm climates.
Predominant in the Mediterranean basin, this plant belongs to the Oleaceae family (comprising nearly 700 species).
Olive leaf is distinguished by six main natural actives: flavonoids, polyphenols, tannins, triterpenes, secoiridoid, and oleuropein.
These actives give olive leaf its numerous health benefits:
- Eliminates free radicals in cells
- Protects against LDL cholesterol and lipid oxidation
- Supports intestinal tract functions
- Maintains normal cholesterol levels
- Promotes healthy blood pressure
- Offers protective effects
- Acts as an antioxidant
Olives, often enjoyed as snacks or part of Mediterranean diets, are rich in oleuropein (in the flesh) and hydroxytyrosol (in the pulp), two natural active compounds known for cardiovascular protection. Two human studies highlight these benefits:
The first, a Spanish, randomized study of 7,216 men and women aged 55-80 at high cardiovascular risk, found that olive oil consumption reduces cardiovascular mortality by 48%! Each additional 10 g of olive oil per day lowers cardiovascular risk by 10%!
The second study, a double-blind, placebo-controlled trial at the University of Auckland in New Zealand, involved 40 moderately overweight adults, with an average age of 46.
They consumed an extract with 51.1 mg of oleuropein and 9.7 mg of hydroxytyrosol daily for three months. Afterward, participants showed a 15% improvement in insulin sensitivity, a 28% increase in pancreatic beta-cell response, and increased fasting interleukin-6 levels.
This treatment helped improve the lives of these moderately overweight adults.
Vitamins B6, B9, and B12
The last actives in Solesterol are vitamins B6, B9, and B12.
This trio of B vitamins is essential in red blood cell formation, enabling cells to navigate clean, fat-free vessels.
In general, vitamins are grouped into two categories (fat-soluble and water-soluble).
Fat-soluble vitamins (A, D, E, K) dissolve in fat, allowing storage in the body.
Water-soluble vitamins (C, B1, B2, B6, B9, B12) dissolve in water.
Vitamin B6 plays a vital role in various body functions:
- Red blood cell formation and energy production
- Synthesis of antibodies, hemoglobin, and neurotransmitters
- Mental balance
- Involved in many essential mechanisms (amino acid and glycogen metabolism)
Vitamin B9 supports cell multiplication and amino acid synthesis, protects the nervous system, and may also have antidepressant effects.
As for Vitamin B12, it’s essential in blood cell creation and renewal, among other functions:
- Reduces cardiovascular risks
- Involved in DNA synthesis
- And more
How is Solesterol different from other herbal treatments for cholesterol management?
- The active ingredients in Solesterol are highly concentrated, allowing a wide variety of active components to be combined in each capsule. For a typical product, it would usually take 3 to 4 capsules to achieve the same results as Solesterol.
- Most products containing fermented black garlic are, at best, standardized to 0.1% s-allyl-cysteine, like ABG10, but often are not standardized at all. Solesterol, however, uses the patented ABG25 extract, meaning the dosage of fermented black garlic is higher in Solesterol.
- All extracts in Solesterol are standardized. This means that each capsule contains the same amount of active ingredients, ensuring consistent effects.
- The product is comprehensive: it addresses cholesterol issues, reduces cardiovascular risk, and supports blood circulation and vascular pressure.
- Solesterol effectively supports the heart and arteries.
- To further support heart function, Solesterol can be paired with Solquinol (our ultra-absorbable Ubiquinol + Vitamin B1 formula).
Box of 60 Capsules (1 to 2 months)
Composition per 2 vegetable capsules (Daily intake)
- Olive Leaf Extract (Olea Europea): 600mg
of which Oleuropein: 120mg
- Fermented Black Garlic Extract (Allium Sativum), patented ABG25 extract: 200mg
of which S-allyl-Cysteine: 0.5mg
- Olive Fruit Extract: 150mg
of which Polyphenols 25% (37.5mg) and Hydroxytyrosol 15% (22.5mg)
- Vitamin B6: 2.8mg (200% NRV)
- Vitamin B9: 400µg (200% NRV)
- Vitamin B12: 24µg (1000% NRV)
No excipients
Vegetable Capsule: hydroxypropylmethylcellulose
1 to 2 daily, ideally with meals, for a minimum of 3 months or as a long-term treatment for enhanced effectiveness, unless otherwise recommended by your healthcare professional.
When to Use Solesterol?
- For high LDL cholesterol levels
- To regulate cholesterol levels
- If you experience difficulty stabilizing blood pressure and circulation
- To support healthy heart and artery function
- In cases of significant hypertension
- If you have trouble forming red blood cells normally
- To maximize protection against free radicals
These details reflect the authorized health claims under European legislation on dietary supplements (EC No 1924/2006), EFSA 2252, 2598, 2599, 2751, 3908, 4009, 4010, 4011.
Possible Side Effects?
- No known side effects at the indicated dosage
- Do not use during pregnancy or breastfeeding
- It is recommended not to exceed the daily recommended dose
- Keep out of reach of children
Over the years, numerous scientific studies have proven the effectiveness of aged fermented black garlic. Its benefits in managing hypertension, for instance, were demonstrated in a 2010 Australian study. This study used aged garlic extract as a supplementary treatment alongside existing antihypertensive medications in patients.
The treated group received four capsules of aged garlic extract (960 mg containing 2.4 mg of S-allylcysteine) per day for 12 weeks. In parallel, a control group received placebos over the same period. Results: for patients with uncontrolled hypertension (SBP ≥ 140 mm Hg initially), systolic blood pressure was on average 10.2 ± 4.3 mm Hg (p = 0.03) lower in the garlic group compared to the control group.
The study concluded that aged garlic extract outperformed placebo in lowering systolic blood pressure, comparable to the effects of current first-line medications. Its benefits are similar to those of current first-line drugs in patients with treated but uncontrolled hypertension.(1)
Further studies on hypertension included two clinical trials conducted in Australia. One study, involving 79 patients with uncontrolled hypertension, administered fermented black garlic extract containing 0.6/1.2 or 2.4 mg of S-allylcysteine per day, resulting in a significant reduction in systolic blood pressure by an average of 11.8 mm Hg after three months of treatment, compared to placebo. (2)
The other Australian clinical trial involved 88 patients with untreated hypertension who received 1.2 mg of S-allylcysteine daily for three months. Similar results were achieved, with an 11.5 mmHg reduction in systolic blood pressure and a 5 mmHg reduction in diastolic blood pressure compared to placebo. The researchers concluded: “Our trial suggests that aged garlic extract is effective in reducing blood pressure at both central and peripheral levels in a significant proportion of patients with uncontrolled hypertension. Additionally, it has the potential to improve arterial stiffness, inflammation, and other cardiovascular markers. The garlic extract was well-tolerated and demonstrated a high degree of safety when used alone or as an adjunct to antihypertensive treatment.” (3)
Garlic’s benefits for metabolism and cardiovascular health have also been scientifically validated. Take, for instance, this Spanish study aimed at analyzing the in vitro cardiovascular effects of an ABG extract enriched with S-allyl-cysteine and polyphenols (ABG10+) in Sprague-Dawley rats.
In the rats' hearts, ABG10+ induced a relaxing effect on coronary arteries before and after IR (Ischemia Reperfusion) and prevented myocardial reduction induced by IR. It also prevented the reduction in myocardial contractility induced by RI. These functional changes were linked to increased expression of both pro- and antioxidant markers as well as pro- and anti-inflammatory markers in the myocardium and aorta. (4)
Another study: Researchers in Singapore, in a placebo-controlled clinical study, demonstrated that supplementation with black garlic significantly reduced cholesterol oxidation in patients with hypercholesterolemia. Fresh white garlic did not yield the same result. It is now understood that excess LDL cholesterol is due to cholesterol oxidation, and researchers believe it is the presence of S-allylcysteine in black garlic responsible for this protective action.(5)
Beyond hypertension and various cardiovascular issues, fermented black garlic offers other health benefits, including potential effects on Alzheimer’s disease. (6) The authors of one study highlight black garlic’s positive effects on cognitive disorders, as well as its neuroprotective, anti-inflammatory, and antioxidant properties in relation to the pathophysiology and degeneration of Alzheimer's disease.
The olive tree, including its leaves, fruit, and even its oil, offers significant benefits in terms of cardiovascular risk reduction and more. Regarding cardiovascular benefits, a well-known American study by researchers at Harvard Medical School demonstrated that just half a tablespoon of olive oil per day reduces cardiovascular risk by 18%. This study followed 61,181 women and 31,797 men over nearly 24 years. Furthermore, it found that replacing 5g of margarine, butter, or mayonnaise each day with an equivalent amount of olive oil reduced heart risk by 7%. (7)
Another study, this time on the fruit: A team of Roman scientists investigated the effect of a single dose of 20 mg of oleuropein (an active compound in olives) in healthy subjects. Compared to the placebo group, they observed a decrease in blood glucose levels and an increase in insulin response, along with a significant inhibition of oxidative stress markers. (8)
Continuing with olive-based compounds, Spanish researchers demonstrated that phenols in olives suppressed the expression of 79 genes related to obesity, dyslipidemia, type 2 diabetes, and inflammation in patients with metabolic syndrome. (9)
The beneficial effect of olive tree compounds against LDL cholesterol was demonstrated in a New Zealand study. This double-blind, randomized, placebo-controlled clinical trial involved 60 pre-hypertensive patients. The experimental group received a daily dose of 136 mg of oleuropein and 6 mg of hydroxytyrosol for six weeks. A significant reduction in diastolic and systolic blood pressure, total cholesterol, LDL levels, and the inflammation marker IL-8 was noted. (10)
In light of numerous compelling scientific studies, the European Food Safety Authority (EFSA) has endorsed health claims for hydroxytyrosol (an active ingredient in olives) concerning its role in protecting blood lipids from oxidative damage: “protection of LDL particles from oxidative damage,” “supports normal HDL levels and blood pressure,” “anti-inflammatory properties,” “contributes to the health of upper airways,” “may aid in maintaining normal gastrointestinal function.” (11)
The last active ingredients in Solesterol are vitamins B6, B9, and B12. Vitamin B6 contributes to (12):
- normal energy metabolism
- normal nervous system function
- normal synthesis of cysteine and homocysteine metabolism
- reduction of fatigue
- normal glycogen and protein metabolism
- normal mental function
- red blood cell formation
- normal immune system function
- regulation of hormonal activity
Vitamin B9 contributes to (13):
- maternal tissue growth during pregnancy
- normal amino acid metabolism
- blood cell formation
- homocysteine metabolism
- normal immune system function
- reduction of fatigue
- normal mental function
- cell division
Lastly, Vitamin B12 contributes to (14):
- normal energy metabolism
- normal nervous system function
- homocysteine metabolism
- normal mental function
- red blood cell formation
- reduction of fatigue
- normal immune system function
- cell division
References
1 Karin Ried, Oliver R. Frank, Nigel P. Stocks (2010) Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: A randomized controlled trial
2 “Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial” Eur J Clin Nutr. 2013; 67(1):64-70
3 The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: The ACE at heart trial” Integr Blood Press Control. 2016; 9: 9-21
4 A.L. García-Villalón, S. Amor, L. Monge, N. Fernández, M. Prodanov, M. Muñoz, A.M. Inarejos-García, M. Granado (2016) In vitro studies of an aged black garlic extract enriched in S-allylcysteine and polyphenols with cardioprotective effects
5 “Aged garlic supplement protects against lipid peroxidation in hypercholesterolemic individuals” J Med Food. 2016; 19(10):931-937
6 Benefits of aged garlic extract on Alzheimer’s disease: possible mechanism of action” Exp Ther Med. 2020; 19(2): 1560-1564
7 “Olive oil consumption and cardiovascular risk in U.S. adults” J Am Coll Cardiol. 2020; 75(15):1729-1739
8 “Oleuropein, a component of extra virgin oil, lowers postprandial glycaemia in healthy subjects” Br J Clin Pharmacol. 2018; 84(7):1566-1574
9 “Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil” BMC Genomics. 2010; 11:253
10 “Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomized controlled trial” Eur J Nutr. 2017; 56(4):1421-1432
11 Regulation EC N° 1924/2006, EFSA J. 2011,9,2033
12 www.vidal.fr/parapharmacie/complements-alimentaires/vitamine-b6-pyridoxine.html
13 www.vidal.fr/parapharmacie/complements-alimentaires/vitamine-b9-m-acide-folique.html
14 www.vidal.fr/parapharmacie/complements-alimentaires/vitamine-b12-cobalamine.html
Solage recommends:
- Most of our nutrients come from France or Europe (local is a priority), except when we can't do otherwise (for curcuma, for example). We never choose ingredients from places or countries where quality is not assured and workers are poorly paid.
- Solage products are designed in France and manufactured according to GMP (Good Manufacturing Practice) standards from the pharmaceutical industry and the HACCP (Hazard Analysis Critical Control Point) method, developed by NASA.
Both methods implement procedures, documents and controls to guarantee perfect traceability and the absence of biological or chemical contamination.
- Solage is a French company, and its products are registered with the relevant authorities.
Solage products are safe, with no bad surprises.
To answer this question, we distinguish between three types of product, depending on their nature and intended purpose:
1/ Ideally taken as a continuous treatment: those which compensate for a nutritional or age-related deficiency, and which serve to restore the body's functions without altering its normal metabolism.
- Common nutritional deficiencies: marine omega-3, vitamin C, magnesium, vitamin D between October and May
- Age-related or pathological deficiencies: Ubiquinol, Glutathione, Iron, Collagen (type I and II)
- To help the body deal with underlying problems: Saffron, Ashwagandha, Men's and women's urinary comfort, cholesterol
2/ To be taken in a cure, but where a break is not necessarily necessary if you or your healthcare professional find it useful:
Detox: Milk thistle, Glutathione
Digestion: Probiotics
3/ Products where a break is useful:
- Curcumin: at least a break of a few days between each box, as it modifies metabolic pathways in the body
- Echinacea (immunity): a break of a few days between each box so as not to over-stimulate the immune system
- Melatonin: avoid taking it every day over the long term, so as not to habituate the body.
In all cases, it's important to remember that the products we offer are genuinely active, that it's important to respect dosage and that they are not a substitute for a varied, balanced diet and a healthy lifestyle.
This will of course depend on the product and your physiological state.
It's worth remembering that physiology is a long-term process, and that it generally takes two to three months, sometimes longer, to achieve a profound change.
However, the feeling is generally quicker, between 15 days and two months.It is then necessary to continue to try to fix these initial results in greater depth.
However, this will be much quicker with subsequent products:
- Melatonin and sublingual GABA, which have a very rapid onset of action (between two minutes and 30 minutes)
- Probiotics (48 hours to two weeks))
Please refer to the “Scientific studies” section of this product page, where you'll find most studies on bioavailability and medium-term effects.