Sublingual GABA, Rhodiola, and Skullcap - SOLAZEN

GABA sublingual, Rhodiola et Scutellaire - Solazen

€32.90
DLUO : 31/10/25
Shipped on : 22 January 2025

+ Convenient for immediate stress and tension. Helps promote both mental and physical relaxation. Quickly reduces feelings of anxiety with a calming effect on the body.

+ Natural formula made from GABA (gamma-aminobutyric acid), Rhodiola Rosea, Scutellaria Baicalensis, and Vitamin B6.

+ 50ml spray bottle with an easy-to-use dosage and a refreshing orange flavor. Oral spray: 4 sprays per use, up to 3 times daily. Vegan-friendly.

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GABA sublingual, Rhodiola et Scutellaire - Solazen
GABA sublingual, Rhodiola et Scutellaire - Solazen

Migraines, loss of appetite, insomnia, fatigue, or dizziness—the physical symptoms of stress vary from person to person, all while impacting their psychological and physical balance. To cope with these ailments, health tips and traditional remedies are often recommended, though they aren’t always fully effective.

Solazen: the natural alternative to stress and anxiety problems.

A unique blend of natural ingredients, Solazen is designed to help the body relax mentally and physically when faced with anxiety. As an immediate support for moments of tension or stress, it works swiftly and naturally to alleviate all forms of anxiety.

One of the key strengths of Solazen lies in its composition. The carefully balanced and natural combination of several active ingredients results in a reliable, high-performance product suitable for all kinds of people, without posing any health risks.

The natural ingredients in Solazen

GABA (Gamma-Aminobutyric Acid)

Gamma-aminobutyric acid, or GABA, is the main inhibitory neurotransmitter in the central nervous system of mammals and birds. A neurotransmitter is a chemical compound released by neurons that acts on other neurons.

GABA’s main role is to slow down signal transmission in the nervous system. Without its stabilizing presence, neurons could overreact and transmit nerve impulses uncontrollably. In adults, GABA prevents excessive and prolonged neuronal activation and plays a neurotrophic role (supporting the growth of certain neurons).

A crucial asset for relaxation, GABA helps slow down heart rate and reduce blood pressure. Its inhibitory properties also provide a calming and relaxing response to anxiety-induced imbalances. GABA has gentle relaxing effects that can promote a stable mood and restorative sleep. Conversely, a lack of GABA is often associated with mood disorders, poor self-control, and excessive worry.

GABA is found in sprouted foods (e.g., sprouted brown rice) and lactic acid bacteria-fermented foods (e.g., yogurt and cheese). In smaller amounts, it is also present in raw spinach, uncooked sweet potatoes, and raw chestnuts. For a daily intake of 600 mg of GABA, you would need to consume 2.34 kg of raw spinach or 1.53 kg of Pecorino cheese. Solazen provides around 133.33 mg of GABA per four-spray dose (which can be repeated three times daily), making it a more efficient option for GABA absorption and assimilation.

Numerous scientific, professional, and reliable studies (see scientific information section) have demonstrated the effectiveness of GABA.

For instance, a 2020 systematic review aimed to show the effects of oral administration of gamma-aminobutyric acid (GABA) on stress and sleep in humans (1). This study analyzed the impact of GABA consumption on stress and sleep in nearly fifteen human and animal studies, concluding that natural and biosynthetic GABA intake can have beneficial effects on stress and sleep.

Rhodiola Rosea

Rhodiola rosea

Rhodiola Rosea is a perennial plant that can reach up to 70 centimeters in height. It belongs to the Crassulaceae family, which includes around 1500 herbaceous plant species. Classified as an adaptogen, Rhodiola Rosea is characterized by a unique triad of criteria:

  • - Non-toxic
  • - Normalizing action that restores or maintains balance
  • - Increases body resistance without stimulating any specific organ

A dioecious plant (with separate male and female plants), Rhodiola Rosea has a thick root called a rhizome. This remarkable root contains nearly 140 natural active compounds (vitamins, minerals, flavonoids, rosavin, salidroside...). Potent ingredients like rosavin and salidroside have anti-stress, anti-aging, and immune-boosting properties (2).

Rosavin, a phenolic glycoside, is present at 5% in Solazen. This rare substance, found only in Rhodiola Rosea’s rhizome, has antidepressant, adaptogenic, and anxiolytic properties (3).

Renowned for ensuring emotional calm, Rhodiola Rosea is effective in stressful situations, helping the body maintain a clear mood and mindset. Often used to promote general well-being, it shines particularly in enhancing mental performance, such as concentration and focus.

Numerous studies have scientifically validated this plant’s virtues (see scientific information section for more examples).

One example is a Russian study from the 2000s involving around sixty foreign students (4). During exam periods, taking Rhodiola Rosea extract significantly improved general well-being and physical and mental performance.

Scutellaria Baicalensis

Baikal Skullcap

Scutellaria Baicalensis, a plant from the mint family, is a phenomenon in traditional Chinese medicine. Native to Russia and Siberia, where the climate is extreme, Scutellaria Baicalensis is famous for its many flavonoids, granting it unique properties:

  • - Baicalein: A flavone compound with biomedical properties.
  • - Baicalin: A flavone compound that plays a role in GABA receptors.
  • - Wogonin: A compound structurally similar to baicalein, with anticoagulant and antiviral properties.

These three main flavonoids make Scutellaria Baicalensis a high-quality nutraceutical plant, capable of acting on nearly the entire body (hips, knees, heart, brain...). Additionally, it has a tranquilizing and relaxing effect, balancing nervous system activity without any side effects or sedation.

Baicalin, present at 70% in the standardized Scutellaria Baicalensis extracts used in Solazen, is highly effective for relaxation and relief. It also improves sleep quality without sedative effects.

Often described as one of the most studied nutraceutical plants globally (see scientific information section for more examples), Scutellaria Baicalensis has undergone extensive research to understand its true benefits.

An example is a 2007 animal study investigating the behavioral changes in stressed mice after consuming Scutellaria Baicalensis and Schisandra chinensis (5). The scientists concluded that equal amounts of S. chinensis and S. baicalensis could potentially be used to treat stress-related disorders.

Vitamin B6

Vitamin B6 is another essential active ingredient in Solazen. Vital for the body's proper functioning due to its many benefits for metabolism, the immune system, and organs, Vitamin B6 boasts several characteristics:

  • Vitamin B6 is a water-soluble vitamin from the B group.
  • There are six active forms of Vitamin B6 in the body: pyridoxal, pyridoxine, pyridoxamine, pyridoxal 5-phosphate, pyridoxine 5-phosphate, and pyridoxamine 5-phosphate.
  • It is abundant in meats (turkey, lamb, veal, chicken...), fatty fish (cod, salmon, tuna...), and offal (liver, sweetbreads, tongue...).
  • It plays a role in the synthesis of neurotransmitters, amino acids, and red blood cells.
  • Excessive intake of pyridoxine can be toxic.
  • Vitamin B6 acts as a cofactor for the enzyme that converts glutamate into GABA.

Popular in the nutraceutical field, Vitamin B6 has been the subject of various scientific studies (see scientific information section for more examples).

An example is a 2018 single-blind, randomized clinical trial examining magnesium and Vitamin B6 intake in healthy adults suffering from severe stress (6). The scientific conclusion suggested that for subjects with severe/extremely severe stress, the study supports the clinical benefits of magnesium combined with Vitamin B6.

Why Choose Solazen Over Other GABA (Gamma-Aminobutyric Acid) Extracts?

To start, Solazen features a natural blend of GABA, Rhodiola Rosea, Baikal Skullcap, and Vitamin B6. Each component brings its own unique benefits and characteristics:

  • GABA, a natural inhibitory neurotransmitter, helps alleviate anxiety symptoms and enhances sleep quality.
  • Vitamin B6 (included in Solazen) supports normal psychological function and the human nervous system.
  • Rhodiola Rosea, enriched with its active compound rosavin, promotes emotional calm during periods of occasional stress.
  • Baikal Skullcap, another plant in Solazen, is rich in flavones and is a scientifically recognized, highly effective natural stress reliever.
  • The combination of GABA and Vitamin B6 is highly beneficial: GABA is produced in the brain from glutamate with the help of the enzyme glutamate decarboxylase (GAD), which uses Vitamin B6 (in the form of pyridoxal-5’-phosphate) as a cofactor.
  • The Baikal Skullcap extract selected for Solazen is known for its potent antioxidant, anxiolytic, and even antidepressant effects.
  • Solazen acts quickly and is easy to use.
  • Its orange-flavored spray ensures a pleasant experience without causing aversion or fatigue for its users.

50ml spray bottle with orange flavor.

Complete Solazen composition per 4 sprays (±0.73 ml):

  • Filler (water)
  • GABA (gamma-aminobutyric acid) 133.33 mg
  • Stabilizer (glycerol)
  • Sweeteners (xylitol and steviol glycosides)
  • Acidity regulator (citric acid)
  • Antioxidant (ascorbic acid)
  • Rhodiola (Rhodiola rosea L.) root extract 20 mg, standardized to ≥5% rosavins
  • Baikal skullcap (Scutellaria baicalensis Georgi) root extract 20 mg, standardized to 70% baicalin
  • Flavor (orange flavor)
  • Preservatives (potassium sorbate and sodium benzoate)
  • Vitamin B6 (pyridoxine hydrochloride) 0.23 mg (16%*)

Spray 4 times into the mouth, under the tongue, up to 3 times a day, whenever needed or at the onset of an anxiety phase.

If you feel the need for a personalized Solazen treatment, we recommend discussing it with your healthcare professional. They will be able to provide the best advice on the appropriate dosage.

When to use Solazen:

  • To relieve stress.
  • To promote healthy sleep.
  • To manage physical and mental stress effectively.
  • To support the body in adapting to emotional stress.
  • To provide beneficial effects for sleep issues, loss of appetite, or decreased work performance.
  • To help stimulate the nervous system, enhance perception, and improve mood.
  • To provide relief from fatigue and stress-induced headaches.
  • To revitalize both body and mind.
  • To support the body’s strength, benefiting the cardiovascular system (protecting against stress and hypertension).

This information complies with authorized health claims in accordance with European legislation on food supplements (EC No. 1924/2006), EFSA 2252, 2598, 2599, 2751, 3908, 4009, 4010, 4011.

Important information and potential side effects:

  • No known side effects for the indicated dosage.
  • Store Solazen in a cool, dry place.
  • If pregnant or breastfeeding, consult your doctor beforehand.
  • Do not exceed the recommended daily dose without the advice of a healthcare professional.
  • Keep out of reach of children: this supplement is not suitable for children under 12 years old.

GABA

With the chemical formula C4H9NO2, gamma-aminobutyric acid is found throughout the brain. Additionally, it is active in about 30 to 40% of synaptic connections in the central nervous system, including the brain, cerebellum, and spinal cord.

There are two main types of GABAergic receptors: the GABA A receptor (located in the cerebral cortex and cerebellum) and the GABA B receptor (found in the thalamus, cerebellum, and spinal cord). To reduce neurotransmitter release, GABA interacts with its receptors. When activated, neurotransmission inhibition begins, inducing a chloride ion flow in GABA A receptors and a calcium ion flow in GABA B receptors simultaneously.

Its various relaxing and sedative properties, along with its effects on the brain, have been scientifically demonstrated multiple times. Here are two examples:

  • Effect on the brain (7): A 2016 review conducted by two scientists titled “GABA Receptors in Brain Development, Function, and Injury.” This comprehensive review, citing nearly a hundred scientific references, explains the structured role of γ-aminobutyric acid in the brain. The findings reveal that GABA:
  1. “Acts as an excitatory agent involved in many neurogenesis processes, including neuronal proliferation, migration, differentiation, preliminary circuit formation, and the development of critical periods.”
  2. “Also plays a role in the development of interstitial white matter neurons and oligodendrocytes.”
  3. “GABAergic system developmental anomalies are particularly relevant in the etiology of schizophrenia.”
  4. “The review also explores GABA’s potential role in mature brain injuries, such as transient ischemia, strokes, and traumatic brain injuries/post-traumatic epilepsy.”
  5. etc.
  • Oral Relaxing Properties (8): A 2016 study by Japanese researchers on “The Effect of Oral γ-aminobutyric Acid (GABA) Administration on Sleep and Its Absorption in Humans.” Sleep was evaluated using electroencephalography after oral GABA administration. The results showed that GABA was quickly absorbed, with the highest blood concentration 30 minutes after ingestion, followed by a subsequent decrease. This validates its oral relaxing effects.

Baikal Skullcap (Scutellaria baicalensis)
 
Baikal Skullcap is a plant rich in flavonoids (flavones) with proven anti-stress effects. It acts quickly and has antioxidant properties:

  • Enhances SOD (superoxide dismutase) levels
  • Reduces lipid peroxidation, with ROS quickly detected in blood plasma

The flavones of Scutellaria are detected very rapidly in blood plasma after oral intake, with baicalin even appearing within 15 minutes. (9)

The Various Mechanisms of Scutellaria baicalensis (4):

1. Neuroinflammation:
Regulates the expression of inflammatory mediators
Inhibits NF-κB activation
Reduces nitric oxide (NO) production 2. Antioxidant Activity:
Enhances SOD (superoxide dismutase) levels
Reduces lipid peroxidation and ROS 3. Anxiolytic and Antidepressant Effects:
Inhibits MAO-A and MAO-B (monoamine oxidase)
Modulates the GABA-A receptor 4. Beta-Amyloid:
Inhibits cholinergic marker generation
Prevents cell death 5. Cerebral Ischemia:
Reduces ROS levels
Inhibits pro-inflammatory cytokines
Decreases nitric oxide production
Reduces oxidative stress
Lowers caspase 3 activity

One of the main flavonoids, baicalin, has been studied for its real effects on depressive and anxious behaviors. For instance, a July 2017 animal study conducted on rats under depressive-like conditions (reduced sucrose intake, lower locomotor activity, increased immobility) demonstrated significant improvements after baicalin treatment (20, 40 mg/kg).

The study specifically confirmed that baicalin has an antidepressant effect, likely linked to the inhibition of NLRP3 inflammasome activation in the rat prefrontal cortex. (10)

Rhodiola Rosea (also known as Golden Root):

Effects of Rhodiola rosea extract on the central nervous system (preclinical studies):

  • Rapid activation and long-term effect: The EEG profile is similar to that of caffeine, guarana, and Ginkgo biloba. (11)
  • Memory: Golden root enhances long-term potentiation (LTP) in the hippocampus, associated with improvements in spatial and temporal memory.
  • Neuroprotection: Modulation profile shows significant upregulation of three GPCR genes, suggesting enhanced spatial and temporal memory.

Clinical Study on Rhodiola Rosea: In a randomized, double-blind, placebo-controlled trial, 60 participants suffering from stress-related fatigue were given 576 mg of Rhodiola extract daily or a placebo for 28 days. Results: a small but statistically significant improvement in burnout scores on the Pines scale, along with a non-significant enhancement in physical and mental health on the SF-36, and no apparent effect on depression scores on the MADRS.

Second Clinical Study on Rhodiola Rosea: Among 10 participants, Rhodiola rosea significantly reduced anxiety, as shown by lower Hamilton scale scores. (12)

Vitamin B6

Vitamin B6 impacts several factors in the human body:

  • Normal energy metabolism
  • Proper functioning of the nervous system
  • Normal synthesis of cysteine and homocysteine metabolism
  • Reduction of fatigue
  • Normal glycogen and protein metabolism
  • Normal mental functions
  • Red blood cell formation
  • Proper immune system functioning
  • Regulation of hormonal activity

References:

  1. Piril Hepsomali, John A. Groeger, Jun Nishihira, Andrew Scholey - Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review - Neuroenergetics, Nutrition and Brain Health - 17 September 2020
  2. Yonghong Li, Victor Pham, Michelle Bui, Liankun Song, Chunli Wu, Arman Walia, Edward Uchio, Feng Smith-Liu, Xiaolin Zi - Rhodiola rosea L.: An Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention - Curr Pharmacol Rep - Dec 2017; 3(6): 384–395.
  3. Marina Perfumi, Laura Mattioli - Adaptogenic and CNS Effects of Single Doses of 3% Rosavin and 1% Salidroside Rhodiola rosea L. Extract in Mice - Phytother Res - Jan 2007; 21(1):37-43.
  4. A A Spasov, V B Mandrikov, I A Mironova - The Effect of Rodakson on the Psychophysiological and Physical Adaptation of Students to Academic Load - Eksp Klin Farmakol - Jan-Feb 2000; 63(1):76-8.
  5. Seungjoo Lee, Dong Hyun Kim, Ji Wook Jung, Ju Hee Oh, Ho Jae Park, Chan Park, Youngbuhm Huh, Jae Hoon Cheong, Tae Hwan Oh, Jong Hoon Ryu - Schizandra chinensis and Scutellaria baicalensis Counter Stress Behaviors in Mice - Phytother Res - Dec 2007; 21(12):1187-92.
  6. Etienne Pouteau, Marmar Kabir-Ahmadi, Lionel Noah, Louise Dye, Juliane Hellhammer, Gisele Pickering, Claude Dubray - Superiority of Magnesium and Vitamin B6 Over Magnesium Alone on Severe Stress in Healthy Adults with Low Magnesemia: A Randomized, Single-Blind Clinical Trial - PLoS One - 2018; 13(12): e0208454.
  7. Connie Wu, Dandan Sun - GABA Receptors in Brain Development, Function, and Injury - Metab Brain Dis - Apr 2015; 30(2): 367–379.
  8. Atsushi Yamatsu, Yusuke Yamashita, Tukaram Pandharipande, Isafumi Maru, Mujo Kim - Effect of Oral γ-Aminobutyric Acid (GABA) Administration on Sleep and Its Absorption in Humans - Food Sci Biotechnol - Apr 2016; 25(2):547-551.
  9. Chung, H.J., et al., Bull. Korean Chem. Soc., 2012. 33(1): p. 177-182.
  10. Xiaoxin Liu, Chao Liu - Baicalin Ameliorates Chronic Unpredictable Mild Stress-Induced Depressive Behavior: Involving the Inhibition of NLRP3 Inflammasome Activation in Rat Prefrontal Cortex - July 2017; 48:30-34.
  11. Dimpfel, W et al., Pharmacol. Pharm. 7, 290–303 (2016).
  12. Bystritsky, A et al., J. Altern. Complement. Med. 14, 175–180 (2008).
  13. www.vidal.fr/parapharmacie/complements-alimentaires/vitamine-b6-pyridoxine.html
FAQ
For a complete cure,
Solage recommends:
FAQ (questions fréquentes)

- Most of our nutrients come from France or Europe (local is a priority), except when we can't do otherwise (for curcuma, for example). We never choose ingredients from places or countries where quality is not assured and workers are poorly paid.

- Solage products are designed in France and manufactured according to GMP (Good Manufacturing Practice) standards from the pharmaceutical industry and the HACCP (Hazard Analysis Critical Control Point) method, developed by NASA.

Both methods implement procedures, documents and controls to guarantee perfect traceability and the absence of biological or chemical contamination.

- Solage is a French company, and its products are registered with the relevant authorities.

Solage products are safe, with no bad surprises.

To answer this question, we distinguish between three types of product, depending on their nature and intended purpose:

1/ Ideally taken as a continuous treatment: those which compensate for a nutritional or age-related deficiency, and which serve to restore the body's functions without altering its normal metabolism.

- Common nutritional deficiencies: marine omega-3, vitamin C, magnesium, vitamin D between October and May

- Age-related or pathological deficiencies: Ubiquinol, Glutathione, Iron, Collagen (type I and II)

- To help the body deal with underlying problems: Saffron, Ashwagandha, Men's and women's urinary comfort, cholesterol

2/ To be taken in a cure, but where a break is not necessarily necessary if you or your healthcare professional find it useful: 

Detox: Milk thistle, Glutathione

Digestion: Probiotics

3/ Products where a break is useful:

- Curcumin: at least a break of a few days between each box, as it modifies metabolic pathways in the body

- Echinacea (immunity): a break of a few days between each box so as not to over-stimulate the immune system

- Melatonin: avoid taking it every day over the long term, so as not to habituate the body.

In all cases, it's important to remember that the products we offer are genuinely active, that it's important to respect dosage and that they are not a substitute for a varied, balanced diet and a healthy lifestyle.

This will of course depend on the product and your physiological state.

It's worth remembering that physiology is a long-term process, and that it generally takes two to three months, sometimes longer, to achieve a profound change.

However, the feeling is generally quicker, between 15 days and two months.It is then necessary to continue to try to fix these initial results in greater depth.

However, this will be much quicker with subsequent products:

- Melatonin and sublingual GABA, which have a very rapid onset of action (between two minutes and 30 minutes)

- Probiotics (48 hours to two weeks))

Please refer to the “Scientific studies” section of this product page, where you'll find most studies on bioavailability and medium-term effects.